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2nd Zing Barriers of The CNS Conference

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We are proud to announce the 2nd Zing Barriers of the CNS Conference which will be held in the Parador Oropesa from Sunday, the 27th until Wednesday, the 30th of September 2015.

The conference aims to provide novel insights into

  1. Latest advances in the area of barrier model systems
  2. The pathophysiology of cerebrovascular and related neuronal diseases associated with changes in drug transport mechanisms and tight junction formation
  3. Cutting edge brain delivery technologies.


Likewise, approaches and perspectives not only from cell culture process and tissue engineers, representatives of translational pharmacokinetics and blood-brain barrier diagnostics but also from vascular physiologists, pharmacologists and neurologists as well as from drug delivery experts are to be combined. In particular, recent findings and developments in the establishment of human pluripotent stem cells as renewable source for endothelial blood-brain barrier (BBB) cells or to microengineered, multicellular BBB structures using a microfluidic chip will be addressed. Moreover, pharmacokinetic models with the purpose to predict drug distribution and permeation into the brain and diagnostic markers will be introduced. The Zing Barriers of the CNS Conference will also refer to cerebrovascular diseases focussing on transporter signaling, the release of biomarkers and changes in tight junction formation that can occur in oncology, during stroke, epilepsy, Alzheimer`s or Parkinson`s disease e.g. including immunological aspects, too. Additionally, autophagocytotic mechanisms and lysosomal storage diseases (Gaucher disease, Sanfilippo syndrome, Hunter syndrome, leukodystrophies) will be featured.To meet the medical needs of an efficient enzyme replacement therapy of lysosomal storage diseases e.g. the latest formulation approaches in the drug delivery field – ranging from fusion proteins, bispecific antibody constructs, modified liposomes, exosomes or nanoparticles or the application of ultrasound – to overcome the blood-brain barrier via receptor-mediated, transcytotic mechanisms will be highlighted in detail.

We hope you will be interested in this preliminary program and join us in the beautiful environment of the former castle of the aristocratic Toledo family for fruitful, broad discussions and an interdisciplinary exchange of thoughts and reflections about CNS barriers. Students are more than welcome and encouraged to actively interact with established scientists. Ample opportunities will be given for networking purposes and poster sessions will be run to finally award the most inspiring presentation. Those aspects and influences could again help to create new collaborations and to draft future directions of novel blood-brain barrier projects unraveling and advancing the challenging field of neurovascular science.

Conference Sponsors


Media Partner

FBCNSFluids and Barriers of the CNS is an open access, peer-reviewed, online journal that considers manuscripts on all CNS fluids and barrier systems in health and disease. Fluids and Barriers of the CNS aims to provide a dedicated avenue for the dissemination of research into all molecular, physiological and pharmacological aspects of brain fluids and barrier systems and their role in neurological disorders. Brain fluids and barriers in general, are subject areas that have not previously had a specialist publishing platform. Until recently, articles have been published in a variety of different journals. This journal provides a dedicated platform, offering quality peer-review of manuscripts. It brings together basic science and clinical experts in brain fluids and barrier systems, promotes synthesis, dialogue and translational research.

The Conference Chair

Mahringer_photoAnne Mahringer
Heidelberg University
Dr. Anne Mahringer studied pharmacy at the Ruprecht-Karls University of Heidelberg and obtained her PhD at the Institute of Pharmacy and Molecular Biotechnology at the Department of Pharmaceutical Technology and Biopharmaceutics under the professorship of Professor Dr. Gert Fricker. After several stays abroad at the NIEHS (National Institute of Environmental Health Sciences, North Carolina), the MDIBL (Mount Desert Island Biological Laboratory, Maine) and the Biomedical Center Uppsala (University Uppsala, Translational PKPD, Sweden) she is currently holding a postdoc position at the Institute of Pharmacy and Molecular Biotechnology at the Department of Pharmaceutical Technology and Biopharmaceutics in Heidelberg. Her research interests focus on drug transporter signaling at the blood-brain barrier and in the kidney as well as on endocytotic transport mechanisms of large peptides across the cerebrovascular endothelium.


Talk Consideration Deadline: 27th August 2015……Poster Submission Deadline: 7th September 2015

For general abstract information or to download a copy of our abstract template please follow the links below.

info-Custom-2 Abstract Information……….Word-Custom Abstract Template Word Format……….pdf-Custom Abstract Template PDF Format

If you have already registered for this conference and now wish to submit your abstract or send a revised version, you can either Sign In to your account and add the abstract or Submit Your Abstract directly to us using the links below.

Sign In………. Submit Your Abstract

The Venue

Parador de Oropesa
Oropesa, Spain



27th September 2015 – 30th September 2015

The Parador Oropesa is majestic in every sense of the word. Located in the beautiful Castillian countryside to the west of Madrid; it is spacious, elegant, and imposing. Set in the former ancestral home of the Counts of Oropesa and located in the shadow of the Sierra de Gredos mountains, over the centuries, its Medieval cloisters and towers have accommodated aristocracy, bishops and soldiers.

There are two castles separated by an immense wall that is crowned by a magnificent machicolated parapet and an awesome tower. At one time the castle complex was controlled by Don Francisco de Toledo – Duke of Alba, and the Viceroy of Peru.  He and later lords added an extended set of palatial rooms and quarters to create what remains today.

The bedrooms are large and spacious with simple Castilian styled, dark wood furniture, with all rooms offer inspiring views – either to the castle tower, the Gredos plains, or the Gredos peaks. There are fine views from any table in the restaurant, with those located against the glass wall on the north side offering particularly stunning panoramic views.


Venue Rating****
Nearest AirportMadrid Barajas
TransfersClick Here


Plenary Speakers


Margareta Hammarlund-Udenaes
Uppsala University
BBB transport and brain tissue binding as drivers of CNS concentrations – regional differences and influence of disease


Timothy M Cox
University of Cambridge
Direct Intracranial Gene therapy for Tay-Sachs and Related Disease


Elga de Vries
VU University Medical Center
Altered neurovascular function: a common denominator in neurological disorders?


Reinhard Gabathuler
biOasis Technologies Inc
Development of New Protein Vectors for the Delivery of Large Therapeutic Compounds to Treat CNS Disorders


Pieter Gaillard
2-BBB Medicines BV
Safely enhancing brain drug delivery using the G-Technology in clinical programs targeting brain cancer and neuro-inflammation


Ingolf Blasig
Leibniz-Institut für Molekulare Pharmakologie
Claudins and the ischemic blood-brain barrier


Ruma Raha-Chowdhury
University of Cambridge
Increased blood-brain barrier vulnerability- iron accumulation to systemic inflammation in Alzheimer disease


Danica Stanimirovic
National Research Council & University of Ottawa
Blood-Brain Barrier Shuttles and Trojans: Development of Brain Targeting Antibody Therapeutics


Svitlana Garbuzova-Davis
University of South Florida
Blood-CNS-Barrier Impairment in ALS: How to Repair?

Invited Speakers

deliMária Deli
Hungarian Academy of Sciences
A versatile lab-on-a-chip tool for modeling biological barriers
alonAlon Friedman
Ben-Gurion University of the Negev & Dalhousie University
Blood-brain barrier dysfunction as a target in the diagnosis and treatment of neurological disorders
gallah-150x150Hans-Joachim Galla
University of Münster
Active and Nanoparticle mediated Transport across the Blood-Brain Barrier in vitro
haseloff-CustomReiner Haseloff
Leibniz-Institut für Molekulare Pharmakologie
Investigations into the Tight Junction Sub-Proteome: Expression and Interaction Analyses
Andreas_ReichelAndreas Reichel
Bayer Pharma
Putting CNS Penetration into the Context of Drug Discovery and Development – Status and Needs from an Industry Perspective
gosseletFabien Gosselet
Université d’Artois
Role of ABC transporters in Amyloid-β and cholesterol exchanges across the blood-brain barrier (BBB): Implications for Alzheimer’s disease.
Leybaert-150x150Luc Leybaert
Ghent University
Connexin channels as calcium-linked targets to prevent inflammatory BBB failure
meairs-150x150Stephen Meairs
Neurologische Universitätsklinik Mannheim
Beyond “opening” the blood-brain barrier with focused ultrasound – new developments and opportunities for drug delivery, transport modulation and treatment of brain disease
Oellinger-150x150Karin Öllinger
Linköping University
The lysosome: from waste bag to potential therapeutic target
Pietrzik-150x150Claus Pietrzik
University Medical Center of the Johannes Gutenberg-University Mainz
Deletion of Lrp1 in brain endothelium demonstrates that the blood-brain barrier is a central pathway for Aβ clearance
tellingen-150x150Olaf van Tellingen
Netherlands Cancer Institute
Brain tumors and the blood-brain barrier in the era of personalized medicine
photo-bourasset-CustomFanchon Bourasset
Université Paris-Descartes

Mouse BBB transport of the Amyloid-beta peptide in physiological and pathological conditions
romero-150x150Ignacio Romero
The Open University
Role of microRNAs in inflammation and ageing at the blood-brain barrier
DSC_6561_mittelWinfried Neuhaus
University Hospital of Würzburg
An in-vitro blood-brain barrier model for ischemia: Validation and Applicability
riganti-CustomChiara Riganti
Università degli Studi di Torino
The regulation of P-glycoprotein at the BBB-tumor interface
rahim-CustomAhad Rahim
University College London
Gene therapy that crosses the BBB – a new way to treat neurometabolic disorders
liebner-CustomStefan Liebner
University Hospital Frankfurt
Astrocyte-derived Wnt growth factors play a role in BBB phenotype regulation and vessel remodeling
lippman-CustomEthan Lippmann
Vanderbilt University
Neurovascular models constructed from human pluripotent stem cells: past results and future directions
Zhang-Wandong-CustomWandong Zhang
University of Ottawa & National Research Council of Canada
Development of FC5hFc-doxorubicin conjugate for drug delivery across the blood-brain barrier

Contributing Speakers

David Begley
Kings College London
Birger Brodin
University of Copenhagen
James R. Connor
Penn State Hershey Medical Center
Maxime Culot
University of Artois
Wandong Zhang
National Research Council of Canada
Vasanthy Narayanaswami
California State University
Iris C. Salaroglio
University of Torino
Sylvia Wagner
Fraunhofer Institute for Biomedical Engineering

Conference Programme

programme-pic-e1436367393550A copy of the conference programme can be accessed via the link below.

Please Note: This programme is subject to change and we strongly recommend periodically reviewing this document.
Conference Programme

Conference Fees

We can offer 3 types of registration for the conference

  • An Event Pass without accommodation
    Provides full conference attendance whilst leaving you free to book your own accommodation.
  • An Event Pass with accommodation.
    This package provides full conference attendance and accommodation at the Parador Oropesa.
  • An Event Pass with shared accommodation.
    Share a room with another delegate at the venue to receive the best priced conference attendance and accomodation package.
Event Pass Only – No Accommodation

Event Pass

Standard Price €750
Standard Price valid from 1st July

Register Now

Event pass fees include

  • Conference registration
  • Welcome reception
  • Attendance to all scientific sessions
  • Conference Pack containing programme & abstract book
  • Wifi in conference room and guest rooms
  • Hot & cold buffet lunches
  • Evening meals on Days 1 & 2 including limited wine/beer/soft drinks
  • All coffee breaks during the conference
  • Poster session
  • Ample time & opportunities for networking
  • On-site assistance from Zing staff available throughout the conference
  • Farewell Dinner Ticket

Event pass fees do not include

  • Accommodation at the conference venue
  • Breakfast

*Please Note: The Earlybird Rate of €620 was valid for those who registered and paid in full by 30th June 2015. Since 1st July, the Event Pass has reverted to the standard price of €750.

Event Pass With Accommodation Packages

Academic Price

Sharer Price
€900 €799

Register Now

Event pass and accommodation package fees include

  • Conference registration
  • Welcome reception
  • Attendance to all scientific sessions
  • Conference Pack containing programme & abstract book
  • Wifi in conference room and guest rooms
  • Hot & cold continental buffet breakfast
  • Hot & cold buffet lunches
  • Evening meals including limited wine/beer/soft drinks
  • Farewell Dinner including local entertainment
  • All coffee breaks during the conference
  • Poster Session
  • 3 Free drink vouchers for selected drinks at the hotel bar
  • 50% discount on all subsequent drinks purchased at the hotel bar
  • Ample time & opportunities for networking
  • On-site assistance from Zing staff available throughout the conference

Accommodation Option
Academic Registrations have a private room. We offer the Sharer rate based on 2 persons sharing a room at the conference.

Please be aware if you book this package you will be sharing a room with another same sex attendee.

If you would like to nominate another attendee to share the room, please notify us of this fact in the ‘Special Requirements’ field of the registration form.

Please Note – Zing has exclusive use of the Parador Oropesa for the duration of the conferences and there are a limited amount of rooms available at the hotel. Until Zing Conferences receives full payment of your invoice, your room will not be reserved and will be allocated on a first-come first-served basis.

The reduced sharer rate of €799 was valid for those who registered and paid in full by 30th June 2015. Since 1st July, the rate has reverted to the standard price of €900. From 24th August, the €799 sharer price was reintroduced as a special offer.

We cannot offer any additional nights accommodation at the Parador before or after the conference dates. Should you require to stay extra nights, we can advise you on alternative accommodation in the local area. Please contact info@zingconferences.com for details


Here are a few alternative accommodation options available in the local area of Oropesa. Please use the links to view each property, the latest rates and reserve your accommodation.


Casa Rural La Posada


Casa Rural La Botica


La Hosteria de Oropesa



Please note: The owner of Casa Rural La Posada only speaks Spanish. Should you wish any information about the property or wish to make a booking, you may use our Spanish speaking colleagues to help. They can be contacted via the following email address zing@islandbridge-events.com

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