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Biology of Human Aging Conference 2014

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Can we devise interventions that will allow us to die young at a very old age?

Chronic diseases are the leading cause of morbidity and the major driver of health costs. The early events that initiate any given chronic disease have been difficult to uncover, partly because many chronic diseases become clinically manifest only once they are mechanistically advanced. Aging is the leading risk factor for nearly all major chronic diseases, including atherosclerosis, cancers, dementias, diabetes, and frailty.

Recent insights support the possibility that aging may be a modifiable risk factor, including the findings that:
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1) Maximum lifespan is extended and age-related diseases are delayed by several single gene mutations, suggesting the pathways affected by these mutations could be therapeutic targets. For example, growth hormone receptor deficiency increases maximum lifespan substantially in mice and leads to delayed cancer in human subjects with the same mutation.
2) Humans who live beyond age 100, a partly heritable trait, frequently have delayed onset of age-related disease leading to compression of morbidity.
3) Caloric restriction, which increases lifespan, is associated with delayed onset of multiple chronic diseases in animal models.
4) Rapamycin increases lifespan and delays cancers and dementia in mouse models.
5) Senescent cell elimination enhances healthspan.
6) Factors made by stem cells from young animals enhance tissue function in older animals.

Since interventions that increase lifespan and healthspan in mammals now exist, we hypothesize that by targeting fundamental mechanisms of aging, clinical interventions can be envisaged that could delay or prevent age-related diseases and disabilities as a group, rather than one at a time.

We aim to bring faculty with expertise spanning the biology of aging to clinical geriatrics to address the following areas:

1) Identification of those basic biological interventions closest to potential translation into clinical practice
2) Healthspan measurement in aging animal models
3) Standardized clinically-relevant stresses in aging experimental animals and use of animal models of human age-related disease
4) Links among basic biologists, clinical geriatricians, and clinical trials investigators
5) Clinical trials paradigms and study populations.

This effort to engage experts who can play a role in devising strategies to delay age-related diseases as a group, instead of one at a time, by targeting fundamental aging mechanisms is critical, timely, and potentially transformative.


Conference Programme

Conference Programme

A copy of the conference programme can be viewed using the above link.
Please note: This schedule will be updated as information is received and is liable to change. We strongly recommend periodically reviewing this document.


Conference Sponsors

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The Conference Chairs

Nir-Barzilai-150x150

Nir Barzilai
Albert Einstein College of Medicine

Kirkland

James Kirkland
Mayo Clinic

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Folkert Kuipers
University Medical Center Groningen


Abstracts

Talk Consideration Deadline: 13th July 2014      Poster Submission Deadline:13th July 2014

For general abstract information or to download a copy of our abstract template please follow the links below.

Abstract Information Abstract Template Word Format Abstract Template .pdf Format

If you have already registered for this conference and now wish to submit your abstract or send a revised version, please use the link below

Submit My Abstract


The Venue

Parador de Oropesa
Oropesa, Spain

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conf-room
outside
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Please Note: While this Parador is situated in Toledo Province, it is not located in the town of Toledo. The town of Toledo and the Parador Toledo are 165Km from Oropesa.

19th September 2014 – 22nd September 2014

The Parador Oropesa is majestic in every sense of the word. Located in the beautiful Castillian countryside to the west of Madrid; it is spacious, elegant, and imposing. Set in the former ancestral home of the Counts of Oropesa and located in the shadow of the Sierra de Gredos mountains, over the centuries, its Medieval cloisters and towers have accommodated aristocracy, bishops and soldiers.

There are two castles separated by an immense wall that is crowned by a magnificent machicolated parapet and an awesome tower. At one time the castle complex was controlled by Don Francisco de Toledo – Duke of Alba, and the Viceroy of Peru.  He and later lords added an extended set of palatial rooms and quarters to create what remains today.

The bedrooms are large and spacious with simple Castilian styled, dark wood furniture, with all rooms offer inspiring views – either to the castle tower, the Gredos plains, or the Gredos peaks. There are fine views from any table in the restaurant, with those located against the glass wall on the north side offering particularly stunning panoramic views.

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Venue Rating****
Nearest AirportMadrid Barajas
TransfersClick here

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Plenary Speakers

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Steven Austad
University of Alabama at Birmingham
Noah’s Ark versus Methuselah’s Zoo: What every Clinician Needs to Know about the Comparative Aging Research.

Steven-Kritchevsky

Stephen Kritchevsky
Wake Forest School of Medicine
Longevity Biomarkers: An Epidemiologic Perspective


Invited Speakers

Rafael-de-CaboRafael de Cabo
NIH/NIA/IRP

Metformin and biology and physiology of aging

Randy-StrongRandy Strong
The University of Texas Health Science Center

Investigating Pharmacological Interventions in the Aging Process: New Findings from the NIA Interventions Testing Program
Ana-Maria-CuervoAna Maria Cuervo
Albert Einstein College of Medicine

Targeting autophagy in aging and age-related diseases

Yousin-SuhYousin Suh
Albert Einstein College of Medicine

GH/IGF1 axis and longevity in humans

JJ-KopchickJohn J. Kopchick
Ohio University

GH Receptor Antagonists; Drugs that can modulate the GH/IGF-1 Axis

Jeff-HalterJeffrey Halter
University of Michigan

Development of clinical trials for longevity drugs in academic settings

Tyler-CurielTyler Curiel
The University of Texas Health Science Center

Clinical trials of Rapamycin in the elderly

Mark-EspelandMark A. Espeland
Wake Forest School of Medicine

Clinical trials of behavioral interventions to extend life

Jill-CrandallJill P. Crandall
Albert Einstein College of Medicine

Resveratrol: therapeutic potential for age-related metabolic disorders

promislowDaniel Promislow
University of Washington

Dogs as a Model for the Biology of Human Aging

sofiya-milmanSofiya Milman
Albert Einstein College of Medicine

Mechanistic biomarkers for exceptional longevity

Harvey-Cohen-150x150Harvey Jay Cohen
Duke University School of Medicine

Clinical Trials Networks: Examples from Geriatric Oncology

kennedy-150x150Brian K. Kennedy
The Buck Institute

Drugs that target the TOR Pathway for Aging and Chronic Disease

luigi-fontana-150x150Luigi Fontana
Washington University in St. Louis & Brescia University

Effects and challenges in adherence to CR in humans
marco-pahor-150x150Marco Pahor
University of Florida

Challenges in recruiting and retaining vulnerable older populations in intervention trials

bart-staels-150x150Bart Staels
Université Lille 2

PPARs in the control of aging-related diseases of the liver

michael-kjaer-150x150Michael Kjær
University of Copenhagen

Loss of Skeletal Muscle with Ageing

martin-lauritzen-150x150Martin Lauritzen
University of Copenhagen

Brain energy supply and metabolism in aging

gerjan-nevis-150x150Gerjan Navis
University Medical Center Groningen

Worlds that should meet – interaction between (mal)-nutrition and pharmacotherapy in the elderly

kenyonCynthia Kenyon
The University of California

Screening for age-delaying drugs

Cornelis-Calkhoven-150x150Cornelis Calkhoven
University Medical Center Groningen

mTORC1-C/EBPβ regulation of healthspan and its translational implications

Felipe-SierraFelipe Sierra
National Institutes of Health

Future plans for Geroscience efforts
studenskiStephanie Studenski
NIH/NIA/IRP

Human and animal models of aging: progress on shared phenotypic characteristics

vergheseJoe Verghese
Albert Einstein College of Medicine

Cognitive-motor perspectives on preventing frailty
joan-mannickJoan Mannick
Novartis Institutes for Biomedical Research

Effects of mTOR inhibition on Immunosenescence in the Elderly

Conference Programme

Conference Programme

A copy of the conference programme can be viewed using the above link.
Please note: This schedule will be updated as information is received and is liable to change. We strongly recommend periodically reviewing this document.


Conference Fees

Event Pass – No Accommodation
Student€799
Academic€799
Industry€799
Optional Extra
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Gala Dinner Attendance€35
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Price includes conference registration and attendance, lunches and coffee breaks.

This option does not include evening meals or accommodation at the venue.

Conference Registration
EarlybirdStandardAccompanying Adult Accompanying ChildExtra Night AdultExtra Night Child
StudentPassed€1200€660€75€115€25
AcademicPassed€1410€660€75€115€25
IndustryPassed€1410€660€75€115€25
Registration & Payment DeadlineMar 18 2014July 24 2014July 24 2014July 24 2014July 24 2014July 24 2014

Delegate Fees: Include conference registration and attendance, accommodation, all meals on a specially negotiated full-board package and The Gala Night (including any accompanying persons).

Accompanying adult Fees: Include the same specially negotiated full-board package as delegates excluding conference attendance.

Additional Night Fees: Prices are per person per night.

Accompanying Children: Persons aged 12 and above are regarded as adults by the hotel. Children under the age of 2 years can stay free of charge.

To ensure maximum safety at our conferences, registered attendee’s children under the age of 18 are not permitted in the conference room, poster room or exhibitors room at any time including during the conference hours and poster sessions.

Registered attendee’s children must be 18 or older to attend the Welcome Reception

The Gala Night is open to all children of registered attendees as long as the child is under the supervision of the parent(s) at all times. Children of attendees who are aged 12 – 17 may attend the Gala Reception if they purchase a reduced cost ticket. Registered attendees children 18 or older must purchase a full price Gala Reception ticket to attend. Please email info@zingconferences.com for information on prices or to book a ticket.

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Additional Information

Group Discounts: We offer group discounts to 2, 4 or 6 attendees from the same lab (based on sharing a twin room), please contact us for more information
Please Note: Your accommodation will not be reserved and conference registration is not confirmed until Zing Conferences Ltd have received full payment of all outstanding fees.

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