Challenges, Solutions and Progress in Stem Cell Medicine
18th – 21st February 2017
The past decade witnessed a significant acceleration in innovative advances towards expanding the therapeutic reach of stem cell medicine. In particular, developments in stem cell science like cellular reprogramming revealed new strategies for approaching previously formidable technical barriers like producing human cells in states and numbers sufficient for effective research and biomedical development. However, despite the remarkable increase in technologies and knowledge, patients are still waiting for new approved, effective treatments based on stem cells and their promise.
There are now many more new stem cell treatment concepts in various orbits about the long-standing stem cell medicine standard, hematopoietic stem cell (HSC) transplantation therapy. Whereas some new concepts emulate the HSC standard, others are a distinct departure from it. Those that model the standard still often face distinctive biological and physiological barriers (e.g., difficulty accessing treatment compartments); and those that depart are often lured away because of distinct practical advantages (e.g., convenient cell sourcing). Therefore, most have one or more limitations or problems that may compromise their efficacy. Even treatment strategies enabled by the tremendous advance of cellular reprogramming technology are limited by the tumorigenicity of reprogrammed cells; and the related genomic and epigenomic mutations of reprogrammed stem cells may also compromise the function of their derivative cells in drug development applications.
So, the past decade’s seemingly accelerated path to success in stem cell medicine is, in fact, cluttered with blocking problems – some preexisting and some introduced by the enabling technologies themselves – that must be cleared before stem cell medicine can realize its promise. The Zing Conference on “Challenges, Solutions, and Progress in Stem Cell Medicine” has the aim of facilitating a reduction in these blocking problems by offering leading practitioners, across the many disciplines of the stem cell medicine field, a unique forum for integrated group dialogue on the main issues limiting better progress in stem cell medicine and on devising solutions.
Conference Topics Addressed
- Transplantation Medicine
- Disease research models
- Drug development applications
II. Stem Cell Medicine Challenges and Solutions
- Sourcing stem cells
- Therapeutic stem cell biomanufacturing
- Quantitative biomarkers for tissue stem cells
- Stem cell tissue engineering
- Differentiating stem cells
- Genomic and epigenomic mutation
- Immunity barriers
- Tissue niche delivery
- Treatment longevity
- Tissue stem cell toxicology
- Tissue stem cells
- Pluripotent stem cells
- Other stem cell types (e.g., placental)
- Homologous stem cell transplantation research
- Heterologous stem cell transplantation research
- Stem cell genetic engineering (e.g., CRISPR/Cas9 technology application)
IV. Stem Cell Medicine: State of the Clinic
- The standard: advances in HSC transplantation medicine
- New stem cell transplantation concepts
- Homologous stem cell transplantation clinical trials
- Heterologous stem cell transplantation clinical trials
- Stem cell gene therapy clinical trials
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The Conference Chair
James L. Sherley
James L. Sherley is an award winning and highly respected scientist. Dr. Sherley founded the Asymmetrex when he was a senior scientist at the Boston Biomedical Research Institute, in June, 2009. Dr. Sherley is a graduate from Harvard College in 1980 with a B.A. degree in biology. He completed a joint M.D. and Ph.D. program from Johns Hopkins University School of Medicine in 1988. After post-doctoral studies at Princeton University, he joined the Fox Chase Cancer Center in Philadelphia as a principal investigator in 1991. In 1998, he moved to the faculty at the Department of Biological Engineering at Massachusetts Institute of Technology, where he pursued the new discipline of adult stem cell biological engineering. Dr. Sherley has won numerous awards and accolades, including the 1993 Pew Scholars in Biomedical Research Award, the 2003 Ellison Medical Foundation Senior Scholar Award in Aging Research, and the 2006 NIH Director’s Pioneer Award. Dr. Sherley has spent twenty years in regenerative biology and stem cell medicine fields. He has focused on elucidating mechanisms responsible for the specialized renewal properties of adult stem cells and using this knowledge to address major research problems limiting the development of adult stem cells for biomedicine.
San Diego. USA.
Located in Rancho Bernardo, this 287-room, 4-star resort has 2 outdoor pools along with a full-service spa providing an idyllic location to serve as a conference host.
All of Rancho Bernardo Inn rooms are air-conditioned and have an array of amenities, including balconies or patios, refrigerators, and coffee makers. Delegates can expect to find free WiFi, bathrooms offering hair dryers and designer toiletries, free bottled water and safes. The bar area provides the perfect setting to continue networking over a drink in relaxed surroundings at the end of the day.
Imperial College London
Peter J. Quesenberry
The Warren Alpert Medical School of Brown University
The New Face of Stem Cell Biology
Bruce M. Boman
Helen F. Graham Cancer Center & Research Institute
Icahn School of Medicine at Mount Sinai
Cato T. Laurencin
University of Connecticut
Regenerative Engineering: Convergence To Address Grand Challenges
Poliambulanza Foundation Hospital
Human term placenta: from biological waste to a precious source of cells for therapeutic application
Auxocell Laboratories Inc
Perinatal Mesenchymal Stem Cell Banking for Umbilical Cord Blood Transplantation
Comprehensive Pain Management Center & Stanford University School of Medicine
University of Texas Health Science Center at Houston.
The Role of Stem Cell Exhaustion in Aging and Disease: Implications for Stem Cell Therapy
Harvard Medical School
Microengineered hydrogels for stem cell bioengineering
Genomics Research Centre & Queensland University of Technology
Human mesenchymal and neural stem cells – can we control lineage fate?
The Austrian Society of Regenerative Medicine
Regenerative medicine for neurological diseases: From clinical trials to clinical guidelines
Contributing speakers will be selected from the abstracts submitted and listed here upon accepting a position on the talk schedule.
A copy of the conference programme can be viewed by using the link below.
Please Note: This programme is subject to change. The programme will be updated regularly as information is received and we will always display the most current version here. We strongly recommend periodically reviewing this document.
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