FBDD Conference 2014
Fragment based drug discovery is now widely recognized as an effective, multi-disciplinary approach to identifying highly efficient chemical matter for small molecule discovery programs. The approval of Zelboraf® has further highlighted how fragments can enable a program for rapid advancement, when effectively prosecuted. The maturation of FBDD has also spawned an explosion in the development and implementation of a host of biophysical tools that are utilized for both screening and characterization. Furthermore, the availability of protein-ligand structural information has provided insight into molecular interactions that are now routinely exploited in fragment optimization. The 2014 fragment based drug discovery conference will focus on state-of-the-art implementation of FBDD at all stages of small molecule identification and optimization. The agenda will feature a number of talks that focus on using FBDD to prosecute a wide array of protein target classes, as well as the implementation of biophysical tools for project enablement. The 2014 FBDD conference will be held at the beautiful Grand Palladium Resort & Spa where ZING’s unique conference format enables a congenial atmosphere highly conducive to extensive discussion and networking.
“During your attendance at the FBDD Conference 2014, you will have the opportunity to interact with many of the premier thinkers and pace-setters in the fragment-based drug discovery field. The tremendous diversity of topics ranging from fragment library design and screening technologies through to case studies, will ensure that you leave with an understanding of not only the current status of the area but also of the future directions. This represents a truly fantastic opportunity to strengthen your knowledge of the area and to share your ideas and experiences in fragment-based methods with world leaders in the field of fragment-based drug discovery.”
Justin Bower & Steve Swann
Registered to attend FBDD 2014? Be sure to take a look at Centers for Disease Control and Prevention page, for information on recommended vaccines and medicines when travelling to the Dominican Republic. Your Doctor will also be able to provide information and advise on this.
The Conference Chairs
Beatson Institute for Cancer Research
Talk Consideration Deadline: 9th May 2014 Poster Submission Deadline: 9th May 2014
For general abstract information or to download a copy of our abstract template please follow the links below.
If you have already registered for this conference and now wish to submit your abstract or send a revised version, please use the link below
Punta Cana, Dominican Republic
The Dominican Republic is the second largest and most diverse Caribbean country, situated just two hours south of Miami, less than four hours from New York and eight hours from most European cities.
Located on the shore of Bávaro Beach, where the Caribbean Sea meets the Atlantic Ocean, the Grand Palladium Punta Bavaro Resort & Spa is part of one of the most important tourist complexes in Punta Cana. This idyllic setting boasts a fully self-contained modern conference centre alongside warm Caribbean sun, a one kilometer beach with fine white sand, transparent turquoise sea and lush tropical vegetation.
Known for their warm and hospitable people, the Dominican Republic is a destination like no other: featuring astounding nature, intriguing history and rich culture.
|Nearest Airport||Punta Cana|
|Transfers & Tours||Click here|
- 8 A la Carte restaurants with a wide variety of cuisines
- 5 Buffet-Style Restaurants
- 14 Bars around the Resort
- 4 Pools
- First-class Spa & Wellness Center
- 24h reception
- Currency exchange
- Laundry service
- Access ramp to common areas and pool
- Supermarket (with a selection of medicine)
- Gift shop/souvenirs
- Medical service
- Two double beds or one large double bed
- Air conditioning and a ceiling fan
- Electronic safe
- Hydromassage bath in the room
- Separate toilet and shower
- Hair dryer
- Magnifying vanity mirror
- Minibar refilled daily with water, soft drinks and beer
- Tea and coffee making facilities
- Iron and ironing board
- Satellite TV
- Radio alarm clock with MP3 player
- Balcony or terrace
- Clothes dryer on terraces.
Vanderbilt University School of Medicine
Cancer Drug Discovery Using Fragment-Based Methods
Scaffold-based Design of Precision Medicine
Fragment Based Drug Design- Back to the Future
Recent experiences of FBDD at Astex
High End GPCR FBDD: Driving Hit Discovery to Candidate Design with Protein Structure, Including Water Network Energetics
Computational enrichment of fragment-led lead finding
Roderick E Hubbard
The University of York
Fragmentology – Current Topics in Fragment-Based Discovery Methods
Attacking Apoptosis with Fragments
Fragment Based Lead Generation: A Rich Source for Designing Selective Bruton’s Tyrosine Kinase Inhibitors
ORS by SPR enables F2L
Extending the range of fragment methodologies: Applications in the absence of crystallography.
Fishing for Fragments to Complement Known Binders
Novel developments in SPR supporting FBDD
Fragonomics: The –omics that will have real impact?
Sanford Burnham Medical Research Institute
NMR-guided fragment based lead discovery against protein-protein interactions
Darren W Begley
Hit finding, characterization and development for infectious disease drug targets using fragments
Baylor College of Medicine
Taking Fragments to the Third Dimension using Diversity-Oriented Synthesis
A Full-Court Press to Tackle the “Undruggable” with Fragments
eFFECTOR Therapeutics, Inc.
Fragment-Based Identification of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors
Fragment-Based Lead Discovery and Design: A Multipronged Approach
University of Lyon
NMR applications in FBDD regarding fragment binding mode and framgent-induced protein conformational change
Francisco X. Talamas
Formerly of Hoffmann-La Roche
Design of novel fragments based on structural information
Inhibition of oxidative protein folding as an approach to target bacterial virulence
Fragment evolution through a modular, clickable fluoromethylketone covalent tag
A copy of the conference programme can be viewed using the above link.
Please note: This schedule will be updated as information is received and is liable to change. We strongly recommend periodically reviewing this document.
|Gala Dinner Attendance||$45|
This option does not include evening meals or accommodation at the venue.
|Standard||Accompanying Adult||Accompanying Child||Extra Night Adult||Extra Night Child|
|Registration Deadline||Jun 30 2014||Jun 30 2014||Jun 30 2014||Jun 30 2014||Jun 30 2014|
Delegate Fees: Include conference registration and attendance, accommodation, all meals and drinks on a specially negotiated all inclusive package and The Gala Night (including any accompanying persons).
Accompanying Persons Fees: Include the same specially negotiated all-inclusive package as delegates excluding conference attendance.
Accompanying Children: Persons aged 12 and above are regarded as adults by the hotel. Children under the age of 18 months can stay free of charge.
A maximum of 2 children can be accommodated per delegate room.
To ensure maximum safety at our conferences, registered attendee’s children under the age of 18 are not permitted in the conference room, poster room or exhibitors room at any time including during the conference hours and poster sessions.
Registered attendee’s children must be 18 or older to attend the Welcome Reception
The Gala Night is open to all children of registered attendees as long as the child is under the supervision of the parent(s) at all times. Children of attendees who are aged 12 – 17 may attend the Gala Reception if they purchase a reduced cost ticket. Registered attendees children 18 or older must purchase a full price Gala Reception ticket to attend. Please email firstname.lastname@example.org for information on prices or to book a ticket.
Extra Night Fees: Prices are per person per night for hotel accommodation outside the conference dates