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Chairs	David Lilley (University of Dundee) Wei Yang (NIH)
Location	The Ocean Coral (*****) Puerto Morelos Mexico Travel, Visas and attractions   Complex   Conference   Restaurant   Room
Date	Wednesday November 10 2010 - Saturday November 13 2010
Synopsis	Nucleic acids - DNA and RNA - play the key informational role in the cell. But they are also structural, regulatory, and they can even behave like enzymes. The DNA in the nucleus bearing the genetic blueprint is frequently copied and transcribed by DNA and RNA polymerases. Yet DNA is wrapped up in chromatin structure and must be manipulated by topoisomerases and helicases to allow its access and usage. RNA achieves complex folds that can recognize and bind small molecules, itself be recognized by proteins, and accelerate chemical reactions by a million fold or more. We are beginning to learn how nucleic acids can achieve these feats.
Confirmed oral presentations	Schedule    ·    Talk Titles Plenary Hong  Li (Florida State University)   James M Berger (University of California Berkeley) Jamie Cate (University of California)   Jennifer Doudna (UC Berkeley/HHMI) Jody  Puglisi (Stanford University)   Jonathan  Widom (Northwestern University ) Philip Bevilacqua (Penn State University)   Smita  Patel (Robert Wood Johnson Medical School) Stephen Kowalczykowski (University of California)   Thomas Steitz (HHMI, Yale University) Invited Chuan He (The University of Chicago)   David Rueda (Wayne State University) Geeta  Narlikar (University of California San Francisco)   Marcin  Nowotny (International Institute of Molecular and Cell Biology in Warsaw) Peter  Cornish (University of Missouri)   Peter Cherepanov (Imperial College London) Saba Valadkhan (Case Western Reserve University)   Yamuna Krishnan (National Centre for Biological Sciences, TIFR) Contributing Andrea Scrima (Friedrich Miescher Institute)   Anita Jones (University of Edinburgh) Barry Stoddard (Fred Hutchinson Cancer Research Center)   Bob Landick (University of Wisconsin-Madison) Carl Correll (Rosalind Franklin University)   Christine Chow (Wayne State University) Dagmar Klostermeier (Biozentrum, University of Basel)   David Nesbitt (JILA/University of Colorado) Gang Lu (NIEHS/NIH)   Garrett Soukup (Creighton University) Jeffrey Kieft (HHMI / University of Colorado School of Medicine)   Jenny Baker (Yale University) John Tainer (The Scripps Research Institute)   Julia Romero (Sudbury Regional Hospital/Northeastern Ontario Regional Cancer Center) Julie Soukup (Creighton University)   Kiyoshi Mizuuchi (NIH) Mario Blanco (University of Michigan)   Olav Schiemann (University St Andrews) Rick Russell (University of Texas at Austin)   Stuart Le Grice (National Cancer Institute) Ya-Ming Hou (Thomas Jefferson University)   Yu Chen (University of Washington) Yves Pommier (LMP, CCR, NCI, NIH)
Abstract submission	Poster abstract deadline:   Friday September 10 2010;   submit your abstract now. To secure your place at the conference, register now.
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Fees	Register Standard Student* Payment deadline Standard  Register $1180 (All-inclusive package) $699 (All-inclusive package) Friday September 10 2010   All-inclusive package:   (conference, accommodation, all food, drinks, social events, etc.) * Students will share a twin room.
	Multiple attendance discount: 3 or more members from the same lab are eligible for a discount. Please contact us. Multiple conference discount: We can offer you a discount if you wish to attend multiple conferences. Please contact us.
Extras	Adult Deadline Extra nights $150 Friday September 10 2010 Accompanying (Standard) $450 Friday September 10 2010   Specially-negotiated all-inclusive rates (including all items listed below, excluding the conference)
Flights	Closest major airport Cancun (CUN), Mexico Scheduled Flights From the US: There are many regular scheduled flights from numerous major US cities & Canadian cities. From Europe, Asia-Pac, etc.: Simply connect at one of the US cities or in Mexico City. All online travel sites or travel agents will advise you on the best route. Use the flight search below to get an idea of cost, schedule and route. Charter Flights There are also many direct charter flights from the US, Canada and Europe. Do a Google search for charter flights Cancun. Current scheduled flight options & costs Departure city / airport code:    Only 2 days until registration closes. Register now. Items included in Nucleic Acids conference 2010 fee ·  Conference ·  Abstract submission ·  ***** accommodation for 3 nights ·  All group meals (breakfast, lunch, dinner) ·  Unlimited local alcoholic beverages and soft drinks (24 hours) ·  All refreshments & social events ·  Non-motorized watersports ·  and more....

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Nucleic Acids conference 2010 schedule

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Confirmed oral presentations

Andrea Scrima (Friedrich Miescher Institute)
Structural basis of UV-damage Recognition and Ubiquitination by the DDB1/2-Cul4 complex
Anita Jones (University of Edinburgh)
Exploring Enzyme-Induced Distortion of the DNA Duplex Using Time-Resolved Fluorescence
Barry Stoddard (Fred Hutchinson Cancer Research Center)
Structures, activity and engineering of homing endonucleases for Gene Targeting
Bob Landick (University of Wisconsin-Madison)
Role of the RNA polymerase trigger loop in nucleotide addition and the regulation of transcript elongation
Carl Correll (Rosalind Franklin University)
RNA chaperone activates a U3 snoRNA switch: implications for ribosome biogenesis
Christine Chow (Wayne State University)
Targeting Dynamic Ribosomal RNA Sites with Small Molecules
Chuan He (The University of Chicago)
Oxidative Nucleic Acid Modification and De-Modification
Dagmar Klostermeier (Biozentrum, University of Basel)
Coordinated conformational changes of DNA gyrase drive strand-passage towards negative supercoiling
David Nesbitt (JILA/University of Colorado)
Temperature dependent RNA folding kinetics and dynamics: An Entropic Origin of Mg2+-Facilitated RNA Folding
David Rueda (Wayne State University)
RNA folding by single molecule FRET
Gang Lu (NIEHS/NIH)
Natural diversity of RNA recognition by PUF proteins
Garrett Soukup (Creighton University)
A putative mammalian riboswitch in the spermine biosynthetic pathway
Geeta Narlikar (University of California San Francisco)
Mechanisms of ATP-dependent chromatin remodeling motors
Hong Li (Florida State University)
James M Berger (University of California Berkeley)
"Catching a motor in the act: the molecular basis for translocation and biased movement in hexameric helicases"
Jamie Cate (University of California)
Structural Biology of Translation: From Escherichia coli to Humans
Jeffrey Kieft (HHMI / University of Colorado School of Medicine)
Molecular mimicry and conformational dynamics at the heart of IRES RNA manipulation of host cell ribosomes
Jennifer Doudna (UC Berkeley/HHMI)
Regulatory RNA biogenesis for viral defense in bacteria
Jenny Baker (Yale University)
An allosteric self-splicing ribozyme triggered by a bacterial second messenger
Jody Puglisi (Stanford University)
Real-time dynamics of translation
John Tainer (The Scripps Research Institute)
Combined X-Ray Scattering (SAXS) and Crystallography to Accurately Characterize Dynamic DNA Repair Complexes in Solution
Jonathan Widom (Northwestern University )
Julia Romero (Sudbury Regional Hospital/Northeastern Ontario Regional Cancer Center)
DNA replication and transcriptional activity at a DBF4 pseudogene locus on human chromosome 10
Julie Soukup (Creighton University)
glms Ribozyme Mechanism and Development of Artificial Agonists as Candidate Antibiotics
Kiyoshi Mizuuchi (NIH)
How do bacteria find the middle of the cell? ATP-driven self-organized dynamic pattern formation by bacterial cell division proteins for septum localization
Marcin Nowotny (International Institute of Molecular and Cell Biology in Warsaw)
Structural studies of RNases H
Mario Blanco (University of Michigan)
Visualizing pre-mRNA structural dynamics during splicing by sm-FRET
Olav Schiemann (University St Andrews)
PELDOR: Obtaining Distances, Orientations and Dynamics of Oligonucleotides
Peter Cornish (University of Missouri)
Peter Cherepanov (Imperial College London)
The mechanism of retroviral DNA integration through X-ray structures of its key intermediates
Philip Bevilacqua (Penn State University)
Mechanism for the HDV ribozyme involving nucleobase and metal ion catalysis
Rick Russell (University of Texas at Austin)
RNA Chaperone Activity of DEAD-box Proteins
Saba Valadkhan (Case Western Reserve University)
Catalysis of splicing by protein-free spliceosomal snRNAs
Smita Patel (Robert Wood Johnson Medical School)
DNA replication dynamics: energetics and coupling of helicase-primase and DNA polymerase
Stuart Le Grice (National Cancer Institute)
Examining the conformational dynamics of reverse transcription by single molecule spectroscopy
Thomas Steitz (HHMI, Yale University)
From understanding antibiotic binding to an RNA machine to designing new antibiotics
Ya-Ming Hou (Thomas Jefferson University)
Synthesis of tRNA(m1G37) by Analogous Enzymes
Yamuna Krishnan (National Centre for Biological Sciences, TIFR)
Delivery Boy to Reporter: Unusual DNA's journey through a worm-whole
Yu Chen (University of Washington)
NMR studies of RNA motions on multiple time scales
Yves Pommier (LMP, CCR, NCI, NIH)
Mitochondrial Topoisomerase I

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