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Chairs	Tom Blundell (University of Cambridge) Jim Wells (UCSF) Chris Murray (Astex Therapeutics,)
Location	The Ocean Coral (*****) Puerto Morelos Mexico Travel, Visas and attractions   Complex   Conference   Restaurant   Room
Date	Saturday December 4 2010 - Tuesday December 7 2010
Synopsis	Knowledge of the sequence of human and pathogen genomes, together with the three-dimensional structures of protein targets, has the potential to accelerate drug discovery. Traditionally, this has been through structure-guided lead optimization but high-throughput structural analyses can also be used to assist lead discovery, often by fragment-screening techniques. X-ray, NMR and other biophysical techniques, as well as computational biology approaches such as virtual screening, are being exploited and candidate drugs developed in this way are in the clinic. This symposium will discuss general principles of structure-guided drug discovery developed over the past decade. It will review recent developments in industry and academia for membrane targets, such as receptors and channels, and complex multiprotein systems involved in cell regulation and signaling, where protein-protein interactions and allosteric sites have often proved challenging. It will also review progress in targeting neglected diseases, particularly infectious diseases such as tuberculosis and malaria.
Programme	View provisional programme. To be considered for any of the remaining speaking slots, please submit your abstract or register now () to secure your place.
Confirmed oral presentations	Schedule    ·    Talk Titles Plenary Brian  Shoichet (University of California San Francisco)   Eddy  Arnold (The State University of New Jersey) Gerhard Klebe (University of Marburg)   Joe Vacca (Merck Frosst Centre for Therapeutic Research) John P.  Overington (European Bioinformatics Institute (EMBL-EBI))   Miles  Congreve (Heptares Therapeutics Limited) Robert M.  Stroud (UCSF)   Tomi  Sawyer (Aileron Therapeutics, Inc.) Wim  Hol (University of Washington)     Invited Celia Schiffer (UMASS )   Corey Strickland (Schering-Plough Research Institute ) Gautam  Sanyal (AstraZeneca R&D Boston, )   James Sacchettini (Texas A&M University) Jean-Paul Renaud (NovAliX)   John Tainer (The Scripps Research Institute) Matthew Jacobson (UCSF)   Max Totrov (Molsoft L L C ) Paul Wyatt (University of Dundee)   Stephen Frye (The University of North Carolina at Chapel Hill ) Contributing Andreas Ziegler (Institut fuer Immungenetik, Charite)   Bernard Maigret (LORIA - Nancy University) Dafydd Jones (Cardiff University)   Euan Murray (University of Edinburgh) Hannu Myllykallio (CNRS UMR7645 - INSERM U696)   Ivet Bahar (University of Pittsburgh) Jan Steyaert (Structural Biology Brussels)   Jan Tavernier (VIB-UGent) Jeffrey Albert (AstraZeneca)   Liang Tong (Columbia University) Rami Hannoush (Genentech)   ross robinson (Oxford University) Salvador Ventura (Universitat Autonoma de Barcelona)   Sandor Vajda (Boston University)
Abstract submission	Poster abstract deadline:   Monday October 4 2010;   submit your abstract now. To secure your place at the conference, register now.
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Fees	Register Standard Student* Payment deadline Standard  Register $1180 (All-inclusive package) $699 (All-inclusive package) Monday October 4 2010   All-inclusive package:   (conference, accommodation, all food, drinks, social events, etc.) * Students will share a twin room.
	Multiple attendance discount: 3 or more members from the same lab are eligible for a discount. Please contact us. Multiple conference discount: We can offer you a discount if you wish to attend multiple conferences. Please contact us.
Extras	Adult Deadline Extra nights $150 Monday October 4 2010 Accompanying (Standard) $450 Monday October 4 2010   Specially-negotiated all-inclusive rates (including all items listed below, excluding the conference)
Flights	Closest major airport Cancun (CUN), Mexico Scheduled Flights From the US: There are many regular scheduled flights from numerous major US cities & Canadian cities. From Europe, Asia-Pac, etc.: Simply connect at one of the US cities or in Mexico City. All online travel sites or travel agents will advise you on the best route. Use the flight search below to get an idea of cost, schedule and route. Charter Flights There are also many direct charter flights from the US, Canada and Europe. Do a Google search for charter flights Cancun. Current scheduled flight options & costs Departure city / airport code:    Only 32 days until registration closes. Register now. Items included in Structural Biology and Drug Discovery conference 2010 fee ·  Conference ·  Abstract submission ·  ***** accommodation for 3 nights ·  All group meals (breakfast, lunch, dinner) ·  Unlimited local alcoholic beverages and soft drinks (24 hours) ·  All refreshments & social events ·  Non-motorized watersports ·  and more....

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Structural Biology and Drug Discovery conference 2010 schedule

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Confirmed oral presentations

Andreas Ziegler (Institut fuer Immungenetik, Charite)
Structure of a classical MHC class I molecule that binds non-classical ligands
Bernard Maigret (LORIA - Nancy University)
Tackling ligand-receptor flexibility in structure-based drug design: application to C-Met kinase
Brian Shoichet (University of California San Francisco)
New Ligands for Old Targets and New Targets for Old Drugs.
Celia Schiffer (UMASS )
Combating Drug Resistance: Lessons from the viral proteases of HIV and HCV
Corey Strickland (Schering-Plough Research Institute )
Structure-Based Design of BACE Inhibitors
Dafydd Jones (Cardiff University)
Intracellular subtilisins: Structural insight into the function and regulation of a novel member of the subtilisin family of serine proteases
Eddy Arnold (The State University of New Jersey)
Targeting Drug-Resistant HIV/AIDS
Euan Murray (University of Edinburgh)
The Development of Peptide Aptamers To Anterior Gradient-2: New tools for investigating the Proteome
Gautam Sanyal (AstraZeneca R&D Boston, )
Gerhard Klebe (University of Marburg)
Binding Sites and Druggability
Hannu Myllykallio (CNRS UMR7645 - INSERM U696)
Antimicrobial compounds targeting the unique reaction mechanism of thymidylate synthase ThyX
Ivet Bahar (University of Pittsburgh)
Druggability of proteins inferred from simulations with new probes: improved theory, expanded coverage, and new horizons
James Sacchettini (Texas A&M University)
Combating drug resistance and persistence in tuberculosis
Jan Steyaert (Structural Biology Brussels)
Nanobodies with G protein like properties stabilize a G Protein-Coupled Receptor Active State
Jan Tavernier (VIB-UGent)
The MAPPIT Toolbox: analysing molecular interactions in human cells
Jean-Paul Renaud (NovAliX)
Non-covalent mass spectrometry in early-stage drug discovery
Jeffrey Albert (AstraZeneca)
Discovery of new high-affinity PDE10 inhibitors using fragment based lead generation and knowledge-based design.
Joe Vacca (Merck Frosst Centre for Therapeutic Research)
Structure Based Approaches towards Novel Antiviral Therapies
John P. Overington (European Bioinformatics Institute (EMBL-EBI))
ChEMBL Database
John Tainer (The Scripps Research Institute)
Allosteric DNA repair machines: insights for biological outcomes and interventions
Liang Tong (Columbia University)
Structure and inhibition of acetyl-CoA carboxylase: an attractive target for drug discovery against diabetes and other human diseases
Matthew Jacobson (UCSF)
Computational Approaches to Drug Discovery
Max Totrov (Molsoft L L C )
Computer Design of Drugs
Miles Congreve (Heptares Therapeutics Limited)
Structure-guided approaches to targeting GPCRs
Paul Wyatt (University of Dundee)
Targetting infectious diseases: trypanosomiasis.
Rami Hannoush (Genentech)
Targeting Wnt Signaling in Cancer
Robert M. Stroud (UCSF)
Structural biology of membrane targets for drug discovery
ross robinson (Oxford University)
Structural basis of semaphorin-plexin signalling
Salvador Ventura (Universitat Autonoma de Barcelona)
Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases
Sandor Vajda (Boston University)
Finding druggable sites in protein-protein interfaces by computational fragment mapping
Stephen Frye (The University of North Carolina at Chapel Hill )
Drug discovery and chromatin remodeling
Tomi Sawyer (Aileron Therapeutics, Inc.)
Stapled Alpha-Helical Peptides: The Twists and Turns of Drug Discovery
Wim Hol (University of Washington)
Targetting infectious disease

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